High and low expression of the hyperpolarization activated current ( I h ) in mouse CA1 stratum oriens interneurons
نویسندگان
چکیده
منابع مشابه
Interneurons in area CA1 stratum radiatum and stratum oriens remain functionally connected to excitatory synaptic input in chronically epileptic animals.
Past work has demonstrated a reduction of stimulus-evoked inhibitory input to hippocampal CA1 pyramidal cells in chronic models of temporal lobe epilepsy (TLE). It has been postulated that this reduction in inhibition results from impaired excitation of inhibitory interneurons. In this report, we evaluate the connectivity of area CA1 interneurons to their excitatory afferents in hippocampal-par...
متن کاملNicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons.
In the brain, high cognitive functions are encoded by coherent network oscillations. Key players are inhibitory interneurons that, by releasing GABA into principal cells, pace targeted cells. Among these, oriens-lacunosum moleculare (O-LM) interneurons that provide a theta frequency patterned output to distal dendrites of pyramidal cells are endowed with HCN channels responsible for the slowly ...
متن کاملMembrane potential and intracellular Ca2+ oscillations activated by mGluRs in hippocampal stratum oriens/alveus interneurons.
Metabotropic glutamate receptors (mGluRs) are expressed heterogeneously in hippocampal interneurons, and their signal transduction cascades remain largely unclear. We characterized an oscillatory response activated by the mGluR agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in hippocampal interneurons of stratum oriens-alveus (OA) with simultaneous whole cell current-clamp...
متن کاملMembrane Potential and Intracellular Ca Oscillations Activated by mGluRs in Hippocampal Stratum Oriens/Alveus Interneurons
Woodhall, Gavin, Christine E. Gee, Richard Robitaille, and (McBain and Dingledine 1993; Morin et al. 1996; Sah et al. Jean-Claude Lacaille. Membrane potential and intracellular Ca 1990). Interneurons of the hippocampal CA1 region receive oscillations activated by mGluRs in hippocampal stratum oriens/ major excitatory inputs from CA3 and/or CA1 pyramidal alveus interneurons. J. Neurophysiol. 81:...
متن کاملContribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons.
Intrinsic GABAergic interneurons provide inhibitory input to the principal neurons of the hippocampus. The majority of interneurons located in stratum oriens (s.o.) of the CA1 region express the hyperpolarization-activated cation current known as I(h). In an effort to elucidate the role of this current in regulating the baseline excitability of these neurons and its participation in the regulat...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2021
ISSN: 2051-817X,2051-817X
DOI: 10.14814/phy2.14848